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Flumethasone Glucocorticoid Receptor agonist

Name: Flumethasone
Brand: Selleck Chemicals
SKU: S4088
Rating: 5 (2 reviews)

Cat.No.S4088

Flumethasone (RS-2177, NSC-54702, Flumetasone) is a Glucocorticoid Receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.

Chemical Structure

Molecular Weight: 410.45

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Quality Control

Batch: S408801 DMSO]82 mg/mL]false]Ethanol]6 mg/mL]false]Water]Insoluble]false Purity: 99.79%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

99.79

Related Targets	Adrenergic Receptor Estrogen/progestogen Receptor GPR Androgen Receptor ACE RAAS Progesterone Receptor Opioid Receptor PGES THR
Other Glucocorticoid Receptor Inhibitors	Corticosterone AL082D06 (20S)-Protopanaxatriol Cortodoxone

Chemical Information, Storage & Stability

Molecular Weight	410.45	Formula	C₂₂H₂₈F₂O₅	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	2135-17-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	RS-2177, NSC-54702,Flumetasone			Smiles	CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C)F

Solubility

In vitro
Batch:

DMSO : 82 mg/mL (199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	glucocorticoid receptor
In vivo	Flumethasone (0.5 mg/100 kg b.w.) reduces insulin-dependent glucose utilization in calves at 24 hours after treatment. This compound combined with sodium ceftiofur reduces the mortality rate in calves with severe acute bronchopneumonia and their clinical and haematological parameters returns to normal significantly faster than in the control calves. It (5 mg) has a significant effect on recovery of uterine disease in cattle with ketosis. This chemical (5 mg) increases plasma glucose concentration and decreases serum beta-hydroxybutyric acid and urine acetoacetate concentrations following treatment in cattle with ketosis. The level of this compound in the treated animals is generally above the detection limit although, in most cases, the concentration is lower than the corresponding Glucocorticoid level in the dexamethasone-exposed calves. It is also detectable in the accompanying urine samples in calves. This chemical binds to plasma transcortin, and it becomes active when it is not bound to transcortin.
References	[1] https://pubmed.ncbi.nlm.nih.gov/9793474/ [2] https://pubmed.ncbi.nlm.nih.gov/9197206/ [3] https://pubmed.ncbi.nlm.nih.gov/8641955/ [4] https://pubmed.ncbi.nlm.nih.gov/12502428/

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