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2BAct

Name: 2BAct
Brand: Selleck Chemicals
SKU: E6589
Rating: 5 (1 reviews)

Cat.No.E6589

2BAct is a potent, orally bioavailable eIF2B activator exhibiting high selectivity (EC50 = 33 nM). It mitigates neurological impairments induced by persistent integrated stress response. This compound demonstrates blood-brain barrier penetration with enhanced solubility and pharmacokinetic properties compared to ISRIB trans-isomer.

Chemical Structure

Molecular Weight: 440.80

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Cited in Nature Medicine for its top-tier quality
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Datasheet

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Chemical Information, Storage & Stability

Molecular Weight	440.80	Formula	C19H16ClF3N4O3	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	2143542-28-1	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

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Mechanism of Action

In vivo	2BAct (300 μg 2BAct/g of meal; 21 weeks) normalises body weight gain in VWM mice. This compound prevents the appearance of motor deficits, myelin loss and reactive gliosis in VWM mice. It stimulates the remaining activity of mutant eIF2B complex in vivo, abrogating the maladaptive stress response.
References	[1] https://pubmed.ncbi.nlm.nih.gov/30624206/

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