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Eicosapentaenoic acid ethyl ester Fatty Acid Synthase modulator

Name: Eicosapentaenoic acid ethyl ester
Brand: Selleck Chemicals
SKU: S6466
Rating: 5 (1 reviews)

Cat.No.S6466

Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.

Chemical Structure

Molecular Weight: 330.50

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Quality Control

Batch: Purity: 99.46%

99.46

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism
Other Fatty Acid Synthase Inhibitors	Denifanstat (TVB-2640) Fatostatin TVB-3664 C75 Betulin FT113 C75 trans Desoxyrhaponticin Praeruptorin B Sodium palmitate

Chemical Information, Storage & Stability

Molecular Weight	330.50	Formula	C₂₂H₃₄O₂	Storage (From the date of receipt)	2 years -20°C liquid
CAS No.	86227-47-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	AMR101, EPA ethyl ester, Ethyl eicosapentaenoate			Smiles	CCOC(=O)CCC\C=C/C/C=C\C\C=C/C/C=C\C\C=C/CC

Solubility

In vitro
Batch:

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (15.13mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (15.13mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	Triglyceride
References	[1] https://pubmed.ncbi.nlm.nih.gov/21683321/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04216251	Completed	Colorectal Adenoma\|Colorectal Cancer\|Endoscopic Surgery\|Eicosapentaenoic Acid\|Gastrointestinal Microbiome	Massachusetts General Hospital\|National Institutes of Health (NIH)	December 9 2020	Phase 1\|Phase 2
NCT03661047	Withdrawn	Colon Cancer	Massachusetts General Hospital\|Harvard School of Public Health (HSPH)	November 30 2019	Phase 2

Tech Support

Handling Instructions

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