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Heparan Sulfate Linear Polysaccharide

Name: Heparan Sulfate
Brand: Selleck Chemicals
SKU: S5992
Rating: 5 (10 reviews)

Cat.No.S5992

Heparan sulfate (HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. Heparan sulfate influences the binding affinity of intestinal epithelium cells (IECs) to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury.

Chemical Structure

Molecular Weight:

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Quality Control

Batch: Purity: 99%

Related Targets	Adrenergic Receptor Estrogen/progestogen Receptor GPR Androgen Receptor Glucocorticoid Receptor ACE RAAS Progesterone Receptor Opioid Receptor PGES
Other Endogenous Metabolite Inhibitors	4-HNE (4-Hydroxynonenal) Ademetionine (S-Adenosylmethionine) Sodium L-lactate 3-Hydroxybutyric acid (BHB acid)

Chemical Information, Storage & Stability

Molecular Weight		Formula	--	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	9050-30-0	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	Wnt
References	[1] https://pubmed.ncbi.nlm.nih.gov/23744737/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06052423	Withdrawn	Extensive Stage Small Cell Lung Cancer (ES-SCLC)	Hansoh BioMedical R&D Company	November 30 2024	Phase 2
NCT05928078	Not yet recruiting	Cognitive Decline	University of Castilla-La Mancha	September 1 2024	Not Applicable
NCT06208735	Not yet recruiting	B-Cell Leukemia\|Non-Hodgkin''s Lymphoma\|B-cell Acute Lymphoblastic Leukemia\|Diffuse Large B Cell Lymphoma\|High-grade B-cell Lymphoma\|Primary Mediastinal Large B-cell Lymphoma (PMBCL)\|Mantle Cell Lymphoma\|B-cell Lymphoma	British Columbia Cancer Agency	July 1 2024	Phase 1
NCT05470322	Not yet recruiting	Hidradenitis Suppurativa\|Scarring	Montefiore Medical Center	June 2024	Not Applicable
NCT06118281	Not yet recruiting	Cardiovascular Risk\|Acute Myocardial Infarction (AMI)	Novo Nordisk A/S\|Duke Clinical Research Institute	June 25 2024	Phase 3

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