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iKIX1 Fungal inhibitor

Name: iKIX1
Brand: Selleck Chemicals
SKU: S1991
Rating: 5 (1 reviews)

Cat.No.S1991

iKIX1 is an antifungal agent and resensitises drug-resistant Candida glabrata to azole antifungals in vitro, which blocks the interaction between the CgGal11A KIX domain and the CgPdr1 activation domain (AD), the IC50 and Ki values are 190.2 μM and 18 μM, respectively.

Chemical Structure

Molecular Weight: 303.17

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Quality Control

Batch: S199101 DMSO]61 mg/mL]false]Ethanol]1 mg/mL]false]Water]Insoluble]false Purity: 99.41%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99.41

Related Targets	Integrase Bacterial Antibiotics Anti-infection Antiviral COVID-19 Parasite Reverse Transcriptase HIV HCV Protease
Other Fungal Inhibitors	Cycloheximide Tolnaftate Manogepix (E1210) Amorolfine HCl Isavuconazole Thimerosal Allicin Neticonazole Hydrochloride Juglone Pseudolaric Acid B

Chemical Information, Storage & Stability

Molecular Weight	303.17	Formula	C₁₀H₈Cl₂N₄OS	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	656222-54-7	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	ClC1=CC=C(NC(=S)NNC(=O)CC#N)C=C1Cl

Solubility

In vitro
Batch:

DMSO : 61 mg/mL (201.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 1 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/26886795/

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Handling Instructions

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