Serine Protease
Other Proteases Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S7380 | Leupeptin Hemisulfate | Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits Cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin. |
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| S3025 | PMSF | PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor. |
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| S1386 | Nafamostat mesilate (FUT-175) | Nafamostat mesilate (FUT-175) is a synthetic serine protease inhibitor used as an anticoagulant during hemodialysis. It blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. This compound also attenuates inflammation and apoptosis. |
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| S8136 | Sivelestat | Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other Proteases. |
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| S7378 | AEBSF HCl | AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor. |
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| S2101 | Gabexate Mesylate | Gabexate Mesylate (FOY) is a serine protease inhibitor with an IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation. |
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| S7218 | Alvelestat (AZD9668) | Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other Serine Protease. This compound is in Phase 2. |
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| S4666 | Sivelestat sodium tetrahydrate | Sivelestat sodium tetrahydrate (ONO5046-Na, EI546, LY544349) is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse. |
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| S7377 | Aprotinin | Aprotinin is a small protein serine protease inhibitor (Kd=0.06 pM for bovine β-trypsin), used to reduce perioperative blood loss and transfusion. |
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| S8457 | UK-371804 HCl | UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). |
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