ULK Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S7949 | MRT68921 HCl | MRT68921 is a potent and dual Autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. |
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| S7885 | SBI-0206965 | SBI-0206965 is a highly selective autophagy kinase ULK1 inhibitor with an IC50 of 108 nM, demonstrating approximately 7-fold selectivity over ULK2. This compound inhibits autophagy and enhances apoptosis in human glioblastoma and lung cancer cells. |
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| S8793 | ULK-101 | ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively. |
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| E1750 | XST-14 | XST-14 is a potent, competitive, and highly selective inhibitor of ULK1 and exhibits an IC50 of 26.6 nM in an in vitro ULK1 kinase activity assay, respectively. This compound reduces the phosphorylation of the ULK1 downstream substrate and induces autophagy inhibition. It exhibits antitumour effects. | ||
| S3393 | SBP-7455 | SBP-7455 is a dual-Specific ULK1/2 Autophagy inhibitor with IC50s of 13 nM and 476 nM for ULK1 and ULK2 in ADP-Glo assay, respectively. | ||
| E1954New | DCC-3116 | DCC-3116 is a selective inhibitor of ULK1/2 that blocks both basal and sotorasib-induced Autophagy in KRAS G12C-driven cell lines and exhibits anti-tumour activity. | ||
| S1092 | KU-55933 | KU-55933 is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy. |
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| S1113 | GSK690693 | GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1. |
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| S7948 | MRT67307 HCl | MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy. |
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| S6386 | MRT67307 |
MRT67307 (IKKε/TBK1 Inhibitor II) inhibits IKKε and TBK1 with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. This compound is also a highly potent ULK1 and ULK2 inhibitor with IC50s of 45 and 38 nM, respectively. It can block autophagy in cells. |
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