ULK Inhibitors

Featured Inhibitors
Inhibitors (10)
Chemical (1)
Agonist (1)
Activator (1)

Cat.No.	Product Name	Information	Product Use Citations
S7948	MRT67307 HCl	MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy.	EMBO Rep, 2025, 10.1038/s44319-025-00444-2 EMBO J, 2024, 10.1038/s44318-024-00244-9 mBio, 2023, 10.1128/mbio.02506-23
S6386	MRT67307	MRT67307 (IKKε/TBK1 Inhibitor II) inhibits IKKε and TBK1 with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. This compound is also a highly potent ULK1 and ULK2 inhibitor with IC50s of 45 and 38 nM, respectively. It can block autophagy in cells.	Front Pharmacol, 2022, 13:924523 Microbiol Spectr, 2022, e0219321
E2012	Ginkgolide K	Ginkgolide K, isolated from Ginkgo biloba, induces protective Autophagy through the AMPK/mTOR/ULK1 signalling pathway, and possesses neuroprotective activity.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S7948

MRT67307 HCl

MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy.

EMBO Rep, 2025, 10.1038/s44319-025-00444-2

EMBO J, 2024, 10.1038/s44318-024-00244-9

mBio, 2023, 10.1128/mbio.02506-23

S6386

MRT67307

MRT67307 (IKKε/TBK1 Inhibitor II) inhibits IKKε and TBK1 with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. This compound is also a highly potent ULK1 and ULK2 inhibitor with IC50s of 45 and 38 nM, respectively. It can block autophagy in cells.

Front Pharmacol, 2022, 13:924523

Microbiol Spectr, 2022, e0219321

E2012

Ginkgolide K

Ginkgolide K, isolated from Ginkgo biloba, induces protective Autophagy through the AMPK/mTOR/ULK1 signalling pathway, and possesses neuroprotective activity.