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NMDAR Agonists

Cat.No. Product Name Information Product Use Citations Product Validations
S2876 (+)-Dizocilpine (MK 801) Maleate (+)-Dizocilpine (MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.(+)-Dizocilpine (MK 801) Maleate can be used to induce animal models of Schizophrenia.
Theranostics, 2025, 15(14):6901-6918
Aging -Albany NY), 2023, 15(12):5698-5712
Aging (Albany NY), 2023, 15(12):5698-5712
S2857 (-)-Dizocilpine (MK 801) Maleate (-)-Dizocilpine (MK 801, Dizocilpine, C13737) Maleate is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
Cancers (Basel), 2024, 16(21)3606
Aging -Albany NY), 2023, 15(12):5698-5712
Aging (Albany NY), 2023, 15(12):5698-5712
Verified customer review of (-)-Dizocilpine (MK 801) Maleate
S4091 Ifenprodil Tartrate Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor; it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.
J Immunother Cancer, 2024, 12(11)e009805
Cancer Sci, 2022, 113(8):2716-2726
Cancer Res, 2021, canres.1017.2021
Verified customer review of Ifenprodil Tartrate
S2043 Memantine HCl Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.
Pharmaceuticals (Basel), 2023, 16(5)692
Front Genet, 2022, 13:942203
FASEB J, 2020, 10.1096/fj.202000534R
S3653 Spermidine trihydrochloride Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
Cell Metab, 2023, S1550-4131(23)00341-8
Int J Mol Sci, 2021, 22(19)10255
Int J Mol Sci, 2021, 22(19), 10255
S4719 Kynurenic acid Kynurenic acid (Quinurenic acid, Kynurenate), a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA receptors.
Cell Prolif, 2025, e70048.
Pharmaceuticals (Basel), 2023, 16(5)692
Gene, 2020, 737:144434
S1330 Felbamate Felbamate (Felbatol, ADD-03055, W-554) is an anticonvulsant drug used in the treatment of epilepsy; NMDAR antagonist.
Anticancer Res, 2021, 41(2):687-697
Neuropharmacology, 2020, 182:108371
S5032 Mephenesin Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is a centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.
Cell Rep Methods, 2023, 3(10):100599
S6644 Radiprodil (RGH-896) Radiprodil (RGH-896) is a NR2B-selective NMDA receptor antagonist, initially developed for the treatment of neuropathic pain.
S0509 NMDAR antagonist 1 NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective antagonist of NMDAR. It has neuroprotective activity.
E1246 D-AP5 D-AP5 (D-APV; D-2-Amino-5-phosphonovaleric acid) is a selective and competitive NMDA receptor antagonist that inhibits the glutamate binding site of NMDA receptors.
S4957 Linalool Linalool (Phantol), a monoterpene compound commonly found as a major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.
S5287 Tiletamine Hydrochloride Tiletamine is a lipophilc and potent veterinary anaesthetic. It is also a NMDA receptor antagonist.
S4745 L-Phenylalanine L-Phenylalanine is an essential amino acid and a competitive antagonist against NMDAR glycine- and glutamate-binding sites with a Kb of 573 μM. It is widely used in food flavour and pharmaceutical production.
E4881 Ifenprodil Ifenprodil (Dilvax, RC 61-91) is a potent antagonist of N-methyl-D-aspartate (NMDA) receptor that selectively inhibits receptors containing the NR2B subunit. It exhibits potential for its use in the treatment of various neurological diseases.
S3535 Deudextromethorphan (AVP-786) Deudextromethorphan (AVP-786) is an active N-methyl-D-aspartate (NMDA) receptor antagonist.
E1771 Cycloleucine Cycloleucine is a specific antagonist of NMDA receptor (N-methyl-D-aspartate receptor coupled glycine receptor), with a Ki of 600 μM. This compound also acts as a specific inhibitor of S-adenosyl-methionine-mediated methylation. It exhibits cytostatic effects.
E1050 PEAQX PEAQX (NVP-AAM077) is an effective and orally available human NMDA antagonist, which shows preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over hNMDA 1A/2B receptors (IC50=29,600 nM).
S5664 Orphenadrine Hydrochloride Orphenadrine Hydrochloride is an uncompetitive NMDAR antagonist, H1 receptor antagonist and nonselective mAChR antagonist with muscle relaxant activity.
S0446 TCN 201 TCN-201 is a selective GluN1/GluN2A (NR1/NR2A) NMDA receptor antagonist with pIC50 6.8 for NR1/NR2A and <4.3 for NR1/NR2B (GluN1/GluN2B), respectively.
S6731 Eliprodil (SL-820715) Eliprodil (SL-820715) is a non-competitive NR2B-selective NMDA antagonist with an IC50 value of 1 μM and is less potent for NR2A- and NR2C-containing receptors with an IC50 > 100 μM.
E2979 DL-AP5 (2-APV) DL-AP5 (2-APV, DL-2-Amino-5-phosphonovaleric acid) is a competitive antagonist of NMDA (N-methyl-D-aspartate) receptor. It shows significantly antinociceptive activity and specifically blocks on channels in the rabbit retina.