Adenosine Receptor Agonists
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S7588 | Reversine | Reversine is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 400 nM/500 nM/400 nM, respectively. Also used for stem cell dedifferentiation. |
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| S8105 | ZM241385 | ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor. |
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| S2790 | Istradefylline | Istradefylline (KW-6002) is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM. Phase 3. |
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| S8104 | SCH58261 | SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a, respectively. |
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| S9608 | Etrumadenant (AB928) | Etrumadenant (AB928, A2aR/A2bR antagonist-1) is a novel dual A2aR/A2bR antagonist, with Kd values of 1.4 nM and 2 nM for A2aR and A2bR, respectively. |
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| S8575 | A2AR antagonist 1 | A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively. |
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| S6646 | Ciforadenant (CPI-444) | Ciforadenant (CPI-444, V81444) is a potent and selective Adenosine A2A receptor antagonist. It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes. |
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| E1310 | DPCPX | DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective adenosine A1 receptor (ADORA1) antagonist, with a Ki of 0.46 nM. |
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| S8720 | Imaradenant (AZD4635) | Imaradenant (AZD4635, HTL1071) is an oral A2AR antagonist that binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other Adenosine Receptor. |
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| S0272 | Derenofylline (SLV320) | Derenofylline (SLV320) is a selective and potent adenosine A1 antagonist with Ki of 1 nM, and it shows selectivity for adenosine A1 over A2A, A2B, and A3 receptors with Ki of 398 nM, 3981 nM, and 200 nM, respectively. | ||
| S4932 | Proxyphylline | Proxyphylline (Monophylline, Spasmolysin) is a derivative of theophylline which is used as a bronchodilator and for its cardiovascular properties. It selectively antagonises A1 adenosine receptors (Ki = 82 nM for bovine brain) versus A2 adenosine receptors (Ki = 850 µM for platelets). | ||
| E4632 | Taminadenant | Taminadenant (NIR178, PBF509) is a non-xanthine and non-furan antagonist of adenosine A2A receptor (A2AR). It can antagonise A2AR agonist-mediated cAMP accumulation and impedance responses with Kb values of 72.8 nM and 8.2 nM, respectively. It exhibits potential utility for Parkinson’s disease (PD) treatment. | ||
| S6639 | BAY-545 | BAY-545 is an A2B adenosine receptor antagonist with ic50 of 59 nM. | ||
| S6910 | Preladenant | Preladenant (Privadenant, SCH 420814, MK-3814) is a potent, competitive and selective antagonist of the human adenosine A2A receptor with Ki of 1.1 nM. | ||
| S2945 | SCH-442416 | SCH-442416 is a selective antagonist of adenosine A2A receptor that binds to human and rat adenosine A2A receptors with Ki of 0.048 nM and 0.5 nM, respectively. | ||
| S5427 | Alloxazine | Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor. | ||
| S3988 | Theophylline-7-acetic acid | Theophylline-7-acetic acid (Acefylline, acetyloxytheophylline, Carboxymethyltheophylline), acting as an Adenosine Receptor antagonist, is a stimulant drug of the xanthine chemical class. |
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